Access Denied
IMPORTANT! If you’re a store owner, please make sure you have Customer accounts enabled in your Store Admin, as you have customer based locks set up with EasyLockdown app. Enable Customer Accounts
FROM WHOLE BLOOD TO A CONCENTRATED BIOLOGICAL PAYLOAD
UP TO
17,6X
EXTRACELLULAR VESICLES
UP TO
18X
PROTEIN AND GROWTH FACTOR CONCENTRATION.
Activation Releases. Concentration Delivers.
Platelet activation releases growth factors, but release alone does not increase their concentration. ExoCube combines activation, filtration, and concentration to maximize the final deliverable biological payload. Independent laboratory evaluation demonstrated approximately 3× enrichment of key growth factors together with 5.8× enrichment of alpha-2-macroglobulin (A2M).
Unlike conventional PRP, which primarily focuses on platelet-derived growth factors, ExoCube also enriches plasma-derived regulatory proteins, creating a broader biological payload designed to support multiple regenerative signaling pathways.
Why Does Concentration Matter?
Two products may contain the same number of platelets yet deliver very different concentrations of measurable bioactive mediators. The difference lies in how those mediators are prepared and concentrated.
A more concentrated biological payload begins with the same platelets.
Independent Laboratory Findings
Following ExoCube™ concentration, 11 biomarkers were evaluated using ELISA assays. Independent laboratory analysis demonstrated approximately three-fold enrichment across all measured platelet-derived growth factors and a 5.8-fold enrichment of the plasma-derived regulatory protein Alpha-2-Macroglobulin (A2M).
~3x
Growth Factors
Average enrichment across all measured platelet-derived growth factors, including PDGF, VEGF, TGF-β, EGF, IGF, HGF, and IRAP.
18X
A2M Enrichment
Observed increase in the concentration of the plasma-derived regulatory protein Alpha-2-Macroglobulin (A2M).
91%
Platelet Recovery
Maximum platelet recovery demonstrated in an independent laboratory evaluation.
11
Biomarker
Total number of biological mediators and proteins evaluated by ELISA.
What Actually Drives the Biological Response?
Platelets contain numerous biologically active mediators involved in tissue signaling. Plasma also contains important regulatory proteins that contribute to the overall biological profile.
Plasma-Derived Regulatory Proteins
Alpha-2-macroglobulin (A2M) — Protease inhibitor; regulates inflammatory cascades.
Interleukin-1 Receptor Antagonist Protein (IRAP) - Anti-inflammatory mediator; regulates IL-1-driven inflammatory cascades.
Platelet-Derived Mediators
- PDGF
- VEGF
- TGF-β
- IGF
- HGF
- EGF
- IL-6
Independent laboratory testing confirmed enrichment of these key plasma-derived mediators.
Traditional Approach
Goal: Maximize platelet recovery.
Focus: Platelet count.
A Different Way of Thinking
Generation III Approach
Deliver more than platelets.
Focus: A concentrated biological payload enriched with measurable growth factors and plasma-derived regulatory proteins.
Platelets are the source. Biological mediators are the payload. EXOCUBE™ does not prepare more platelets. It prepares a more concentrated biological payload from the platelets already recovered.
Key Takeaway
EXOCUBE™ is designed to prepare a more concentrated measurable biological payload, not simply more platelets.
The future of autologous biologics is defined not only by platelet count, but by the measurable biological composition of the final preparation.
Generation III Autologous Biologics
Traditional PRP
How many platelets?
Focus: Platelet count. The biological composition of the final preparation remains a secondary consideration.
EXOCUBE™
How much measurable biological payload can be prepared from the patient’s own blood?
Focus: Preparing a concentrated biological payload enriched with measured growth factors, plasma-derived regulatory proteins, and platelet-associated biological mediators.
Why Does It Matter in Clinical Practice?
ExoCube™ provides physicians with a standardized workflow that integrates activation, filtration, and concentration within a closed, single-use system. Independent laboratory evaluation demonstrated efficient platelet recovery together with enrichment of multiple measured biological mediators following processing.
Approximately 30-Minute Workflow
A fast and efficient workflow that integrates easily into existing clinical routines.
Closed, Single-Use System
Designed to help minimize the risk of contamination through a closed, single-use system.
Standardized Workflow
Designed to reduce protocol-to-protocol variability and support consistent, reproducible
preparation.
Autologous Biologics Procedure
Designed for seamless integration into existing PRP workflows while supporting the introduction of a differentiated premium autologous biologics procedure.
Invalid password
Enter